Data as of Q4 2025 (Dec 31, 2025)

TANG CAPITAL MANAGEMENT LLC

โ€ขCIK: 1232621โ€ขFiling: Q4 2025

**TANG CAPITAL MANAGEMENT LLC** manages $2.0B across a diversified portfolio of 75 positions. The firm maintains significant exposure to key names, notably anchoring its top holdings with AUPH at $180.7M and GLPG at $128.2M. Further concentration is evident in PTCT ($113.9M) and CELC ($104.7M), suggesting a conviction-driven approach within its investment mandate. This structure highlights tactical allocation across several high-conviction names.

Total AUM
$2.0B
QoQ Performance
-22.1%
Positions
75
Top 10 Concentration
52.9%
Latest Filing
Q4 2025

Top Holdings Allocation

AUPH
GLPG
PTCT
CELC
AUPH8.9%
GLPG6.3%
PTCT5.6%
CELC5.2%
MIRM4.8%
TARS4.8%
KINIKSA4.6%
IMCR4.5%

๐Ÿ“ˆ Biggest Buys

RNAGBP
AVIDITY BIOSCIENCES INC
NEW
3.2% of portfolio
CAPR
CAPRICOR THERAPEUTICS INC
NEW
2.4% of portfolio
SPY
SPDR S&P 500 ETF TR
NEW
1.0% of portfolio
BNTX
BIONTECH SE
+74.1%
2.2% of portfolio
BSFA
ANI PHARMACEUTICALS INC
+51.6%
1.9% of portfolio

๐Ÿ“‰ Biggest Sells

TARS
TARSUS PHARMACEUTICALS INC
-51.6%
4.8% of portfolio
SYRE
SPYRE THERAPEUTICS INC
-40.9%
3.1% of portfolio
VRDN
VIRIDIAN THERAPEUTICS INC
-36.9%
2.8% of portfolio
ACAD
ACADIA PHARMACEUTICALS INC
-80.0%
0.4% of portfolio
PGEN
PRECIGEN INC
-54.7%
1.2% of portfolio

Sector Breakdown

Other96.5%
Technology1.9%
ETF1.0%
Healthcare0.5%

๐Ÿšช Exited Positionssold since Q3 2025

2GH
MERUS N V
SOLD
$56.5M
RLAY
RELAY THERAPEUTICS INC
SOLD
$42.1M
VERA
VERA THERAPEUTICS INC CL A
SOLD
$39.2M
NKE
NIKE INC
SOLD
$36.2M
ISI
IONIS PHARMACEUTICALS INC
SOLD
$36.0M
+123 more exited positions

Changes from Q3 2025

NEW9 new positions
โ†‘12 increased
โ†“38 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023