Data as of Q4 2025 (Dec 31, 2025)
SYRE

SPYRE THERAPEUTICS INC

Institutional Ownership · Q4 2025

Filing: Q4 2025

SPYRE THERAPEUTICS INC (SYRE) is held by 147 institutional investors with combined holdings of $2.7B. Major holders include FMR LLC, BlackRock, Inc. (BLK), RTW INVESTMENTS, LP.

💰 Dark Pool Activity👤 Insider Trades
Institutional Holders
147
Total Value
$2.7B
Ownership %
93.9%

🏦 Top Institutional Holders

FMR LLC
11.6M shares
$381.3M
13.49% ownership
BlackRock, Inc. (BLK)
5.5M shares
$180.9M
6.40% ownership
RTW INVESTMENTS, LP
4.2M shares
$136.7M
4.84% ownership
VANGUARD GROUP INC
4.0M shares
$132.2M
4.68% ownership
Fairmount Funds Management LLC
4.0M shares
$131.6M
4.66% ownership

📊 Financials

Income statement, balance sheet, and cash flow from SEC filings.

🏦 Browse Funds

See complete portfolios of top hedge funds.

🎯 AI Signals

Find stocks where multiple funds are accumulating.