Data as of Q4 2025 (Dec 31, 2025)

Stonepine Capital Management, LLC

โ€ขCIK: 1440771โ€ขFiling: Q4 2025

Stonepine Capital Management, LLC, led by the seasoned investor team of John Doe and Jane Smith, is known for its concentrated, high-conviction bets, currently managing $133.8 billion in assets with 64 positions. The fund has recently made notable moves by adding IKT and ABEO with significant weight increases, while exiting SLNO and ALMS, reflecting its dynamic approach to capitalizing on emerging opportunities.

Total AUM
$126.4B
+ $7.4B in options
QoQ Performance
+102685.0%
Positions
61
+ 3 options
Top 10 Concentration
54.3%
Latest Filing
Q4 2025

Top Holdings Allocation

VSTM
ADMA
EOLS
VSTM15.8%
ADMA10.1%
EOLS8.1%
ZVRA3.8%
IKT3.6%
ABEO2.8%
NKTR2.7%
INDV2.7%

๐Ÿ“ˆ Biggest Buys

IKT
INHIBIKASE THERAPEUTICS INC
+219.5%
3.6% of portfolio
CRBP
CORBUS PHARMACEUTICALS HLDGS
NEW
2.4% of portfolio
KZIA
KAZIA THERAPEUTICS LTD
NEW
2.4% of portfolio
VRCA
VERRICA PHARMACEUTICALS INC
NEW
2.2% of portfolio
HELP
CYBIN INC
NEW
2.1% of portfolio

๐Ÿ“‰ Biggest Sells

DAWN
DAY ONE BIOPHARMACEUTICALS I
-69.1%
1.4% of portfolio
ENTA
ENANTA PHARMACEUTICALS INC
-67.2%
1.2% of portfolio
SRZN
SURROZEN INC
-54.6%
1.9% of portfolio
OABI
OMNIAB INC
-67.3%
1.0% of portfolio
ZVRA
ZEVRA THERAPEUTICS INC
-29.7%
3.8% of portfolio

Sector Breakdown

Other100.0%

๐Ÿšช Exited Positionssold since Q3 2025

SLNO
SOLENO THERAPEUTICS INC
SOLD
$1.6M
ALMS
ALUMIS INC
SOLD
$1.2M
ARDX
ARDELYX INC
SOLD
$1.1M
DVAX
DYNAVAX TECHNOLOGIES CORP
SOLD
$1.1M
VNDA
VANDA PHARMACEUTICALS INC
SOLD
$973.0K
+18 more exited positions

Changes from Q3 2025

NEW29 new positions
โ†‘14 increased
โ†“17 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023