Data as of Q4 2025 (Dec 31, 2025)

Spruce Street Capital LP

โ€ขCIK: 2050194โ€ขFiling: Q4 2025

**Spruce Street Capital LP** manages $303M across a concentrated portfolio of 27 positions. The fund exhibits significant conviction in select names, notably maintaining a substantial allocation to CDTX at $51.3M. Key holdings also include RLAY ($25.2M), LBRX ($22.4M), and RLMD ($19.7M), suggesting a focused, high-conviction investment mandate. This structure indicates a tactical approach targeting outsized returns within specific market sectors.

Total AUM
$302.7M
QoQ Performance
N/A
Positions
27
Top 10 Concentration
70.8%
Latest Filing
Q4 2025

Top Holdings Allocation

CDTX
RLAY
LBRX
RLMD
PCVX
KINI
EYPT
CDTX17.0%
RLAY8.3%
LBRX7.4%
RLMD6.5%
PCVX6.1%
KINIKSA5.9%
EYPT5.9%
YB4P4.8%

๐Ÿ“ˆ Biggest Buys

CDTX
CIDARA THERAPEUTICS INC
NEW
17.0% of portfolio
RLAY
RELAY THERAPEUTICS INC
NEW
8.3% of portfolio
LBRX
LB PHARMACEUTICALS INC
NEW
7.4% of portfolio
RLMD
RELMADA THERAPEUTICS INC
NEW
6.5% of portfolio
PCVX
VAXCYTE INC
NEW
6.1% of portfolio

๐Ÿ“‰ Biggest Sells

No reductions this quarter

Sector Breakdown

Other100.0%