Soleus Capital Management, L.P.
โขCIK: 1802630โขFiling: Q4 2025
**Soleus Capital Management, L.P.** manages $2.7B across a diversified portfolio of 95 positions. The fund maintains significant exposure to the technology and specialized sector, highlighted by its top holding in XBI at $353.6M. Further concentration is evident in KRYS ($232.0M) and CELC ($180.4M), suggesting a focused, high-conviction approach to growth assets. This structure indicates a tactical allocation strategy targeting outsized returns within select market segments.
Total AUM
$2.4B
+ $353.6M in options
QoQ Performance
+26.0%
Positions
94
+ 1 option
Top 10 Concentration
51.5%
Latest Filing
Q4 2025
Top Holdings Allocation
XBI
KRYS
CELC
XBI13.0%
KRYS8.6%
CELC6.7%
NVCR4.1%
PRAX3.9%
TGTX3.5%
DC43.2%
BMRN2.9%
๐ Biggest Buys
๐ Biggest Sells
Sector Breakdown
Other100.0%
๐ช Exited Positionssold since Q3 2025
+20 more exited positions
Changes from Q3 2025
NEW32 new positions
โ23 increased
โ35 decreased
Historical Filings
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023