Data as of Q4 2025 (Dec 31, 2025)

Sofinnova Investments, Inc.

โ€ขCIK: 1631134โ€ขFiling: Q4 2025

**Sofinnova Investments, Inc.** manages $2.3B across a concentrated portfolio of 60 positions. The fund exhibits significant conviction in the healthcare sector, with top holdings including NTRA at $355.2M and MRX at $163.2M. Further notable allocations include AZN ($150.1M) and VERA ($141.5M), signaling a deep focus on innovative biopharma and life sciences opportunities. This structure suggests a high-conviction, sector-specific mandate within the healthcare value chain.

Total AUM
$2.3B
QoQ Performance
+50.4%
Positions
60
Top 10 Concentration
54.2%
Latest Filing
Q4 2025

Top Holdings Allocation

NTRA
JAZZ
AZN
VERA
NTRA15.3%
JAZZ7.0%
AZN6.5%
VERA6.1%
BMY3.5%
UTH3.3%
VRTX3.2%
ABBV3.1%

๐Ÿ“ˆ Biggest Buys

BMY
BRISTOL-MYERS SQUIBB CO
NEW
3.5% of portfolio
AZN
ASTRAZENECA PLC
+98.1%
6.5% of portfolio
LLY
ELI LILLY & CO
NEW
2.9% of portfolio
JAZZ
JAZZ PHARMACEUTICALS PLC
+63.0%
7.0% of portfolio
BMRN
BIOMARIN PHARMACEUTICAL INC
NEW
1.8% of portfolio

๐Ÿ“‰ Biggest Sells

AXSM
AXSOME THERAPEUTICS INC
-96.9%
0.1% of portfolio
ROIV
ROIVANT SCIENCES LTD
-76.7%
0.7% of portfolio
EXK
EXACT SCIENCES CORP
-72.2%
0.4% of portfolio
DC4
DEXCOM INC
-51.5%
1.1% of portfolio
PRAX
PRAXIS PRECISION MEDICINES INC
-27.3%
1.6% of portfolio

Sector Breakdown

Other90.5%
Healthcare9.5%

๐Ÿšช Exited Positionssold since Q3 2025

GILD
Gilead Sciences Inc
SOLD
$139.0M
BSX
Boston Scientific Corp
SOLD
$55.6M
IBB
iShares TR
SOLD
$46.9M
XBI
SPDR Series Trust
SOLD
$40.1M
AKRO
Akero Therapeutics Inc
SOLD
$22.5M
+5 more exited positions

Changes from Q3 2025

NEW11 new positions
โ†‘23 increased
โ†“18 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023