Data as of Q4 2025 (Dec 31, 2025)

SECTORAL ASSET MANAGEMENT INC

โ€ขCIK: 1274413โ€ขFiling: Q4 2025

**SECTORAL ASSET MANAGEMENT INC** A $125M-AUM manager employing a concentrated, sector-focused strategy across 74 positions. The portfolio exhibits significant overweighting in the biotechnology and healthcare sectors, evidenced by top holdings including EVMN ($10.1M) and CTNM ($9.2M). Key allocations also target established pharmaceutical leaders such as LLY ($7.8M), SI ($7.0M), and UNH ($4.5M). This structure suggests a deep conviction in high-growth, specialized healthcare value plays.

Total AUM
$124.8M
QoQ Performance
-23.0%
Positions
74
Top 10 Concentration
46.1%
Latest Filing
Q4 2025

Top Holdings Allocation

EVMN
CTNM
LLY
SI
EVMN8.1%
CTNM7.3%
LLY6.3%
SI5.6%
UNH3.6%
AMGN3.4%
JNJ3.4%
ABBV3.1%

๐Ÿ“ˆ Biggest Buys

EVMN
EVOMMUNE INC
NEW
8.1% of portfolio
COGT
COGENT BIOSCIENCES INC
NEW
0.9% of portfolio
JNJ
JOHNSON & JOHNSON
+32.7%
3.4% of portfolio
AMGN
AMGEN INC
+26.4%
3.4% of portfolio
SI
SHOULDER INNOVATIONS
+14.4%
5.6% of portfolio

๐Ÿ“‰ Biggest Sells

GPCR
STRUCTURE THERAPEUTICS
-89.2%
1.3% of portfolio
VTYXUSD
VENTYX BIOSCIENCES
-91.2%
0.7% of portfolio
RCUS
ARCUS BIOSCIENCES
-84.5%
1.1% of portfolio
โ€”
IMMATICS NV
-88.8%
0.5% of portfolio
KURA
KURA ONCOLOGY
-86.3%
0.5% of portfolio

Sector Breakdown

Other70.0%
Healthcare30.0%

๐Ÿšช Exited Positionssold since Q3 2025

ANAB
ANAPTYSBIO INC
SOLD
$6.0M
BCAX
BICARA THERAPEUTICS
SOLD
$4.2M
SLDB
SOLID BIOSCIENCES
SOLD
$3.9M
MBX
MBX BIOSCIENCES INC
SOLD
$3.4M
XBI
SPDR SERIES TRUST
SOLD
$3.4M
+9 more exited positions

Changes from Q3 2025

NEW6 new positions
โ†‘20 increased
โ†“44 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023