Sarissa Capital Management LP
โขCIK: 1577524โขFiling: Q4 2025
**Sarissa Capital Management LP** A $223M-AUM fund maintaining a focused portfolio of 9 positions. The strategy is anchored by significant allocations to INVA ($56.3M) and IRWD ($53.6M), representing the core of the current deployment. Further concentration is evident in NBIX ($43.0M), while the remaining holdings include CYTK ($25.2M) and EH3 ($23.4M). This structure suggests a conviction-driven approach across select, high-conviction names.
Total AUM
$222.9M
QoQ Performance
+23.6%
Positions
9
Top 10 Concentration
100.0%
Latest Filing
Q4 2025
Top Holdings Allocation
INVA
IRWD
NBIX
CYTK
EH3
LNTH
INVA25.3%
IRWD24.1%
NBIX19.3%
CYTK11.3%
EH310.5%
LNTH5.4%
BHVN2.6%
REGN1.5%
๐ Biggest Sells
CYTK
CYTOKINETICS INC
-32.6%
11.3% of portfolio
Sector Breakdown
Other100.0%
Changes from Q3 2025
NEW1 new position
โ1 increased
โ1 decreased
Historical Filings
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023