Data as of Q4 2025 (Dec 31, 2025)

Sarissa Capital Management LP

โ€ขCIK: 1577524โ€ขFiling: Q4 2025

**Sarissa Capital Management LP** A $223M-AUM fund maintaining a focused portfolio of 9 positions. The strategy is anchored by significant allocations to INVA ($56.3M) and IRWD ($53.6M), representing the core of the current deployment. Further concentration is evident in NBIX ($43.0M), while the remaining holdings include CYTK ($25.2M) and EH3 ($23.4M). This structure suggests a conviction-driven approach across select, high-conviction names.

Total AUM
$222.9M
QoQ Performance
+23.6%
Positions
9
Top 10 Concentration
100.0%
Latest Filing
Q4 2025

Top Holdings Allocation

INVA
IRWD
NBIX
CYTK
EH3
LNTH
INVA25.3%
IRWD24.1%
NBIX19.3%
CYTK11.3%
EH310.5%
LNTH5.4%
BHVN2.6%
REGN1.5%

๐Ÿ“ˆ Biggest Buys

EH3
AMARIN CORP PLC
+34.7%
10.5% of portfolio
BHVN
BIOHAVEN LTD
NEW
2.6% of portfolio

๐Ÿ“‰ Biggest Sells

CYTK
CYTOKINETICS INC
-32.6%
11.3% of portfolio

Sector Breakdown

Other100.0%

Changes from Q3 2025

NEW1 new position
โ†‘1 increased
โ†“1 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023