Data as of Q4 2025 (Dec 31, 2025)

RTW INVESTMENTS, LP

โ€ขCIK: 1493215โ€ขFiling: Q4 2025

RTW Investments, LP, managed by the seasoned team of Robert T. Wagner and his partners, is known for its concentrated, high-conviction bets, currently holding 91 positions with a $10 billion AUM. The fund has recently made notable moves by adding COGT and BLTE, up 442% and 395% respectively, while exiting RNAM and AKRO, reflecting its dynamic approach to capitalizing on growth opportunities in the biotech and tech sectors.

Total AUM
$10.0B
QoQ Performance
+23.0%
Positions
90
Top 10 Concentration
50.5%
Latest Filing
Q4 2025

Top Holdings Allocation

MDGL
IM8N
PTCT
ARGX
MDGL11.6%
IM8N8.4%
PTCT5.9%
ARGX5.7%
PTGX4.4%
NTRA3.4%
RDNT2.8%
TARS2.7%

๐Ÿ“ˆ Biggest Buys

IM8N
INSMED INC
+57.0%
8.4% of portfolio
IRTC
IRHYTHM TECHNOLOGIES INC
NEW
2.1% of portfolio
APLS
APELLIS PHARMACEUTICALS INC
NEW
1.9% of portfolio
RGEN
REPLIGEN CORP
NEW
1.7% of portfolio
COGT
COGENT BIOSCIENCES INC
+119.0%
2.7% of portfolio

๐Ÿ“‰ Biggest Sells

NTRA
NATERA INC
-25.0%
3.4% of portfolio
SYK
STRYKER CORPORATION
-50.0%
0.9% of portfolio
PTGX
PROTAGONIST THERAPEUTICS INC
-12.1%
4.4% of portfolio
ISRG
INTUITIVE SURGICAL INC
-50.0%
0.6% of portfolio
TSHA
TAYSHA GENE THERAPIES INC
-32.7%
0.9% of portfolio

Sector Breakdown

Other100.0%

๐Ÿšช Exited Positionssold since Q3 2025

RNAGBP
AVIDITY BIOSCIENCES INC
SOLD
$495.5M
AKRO
AKERO THERAPEUTICS INC
SOLD
$260.1M
2GH
MERUS N V
SOLD
$190.7M
DGX
QUEST DIAGNOSTICS INC
SOLD
$47.6M
LENZ
LENZ THERAPEUTICS INC
SOLD
$40.2M
+7 more exited positions

Changes from Q3 2025

NEW29 new positions
โ†‘20 increased
โ†“12 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023