Data as of Q4 2025 (Dec 31, 2025)

Rock Springs Capital Management LP

โ€ขCIK: 1595725โ€ขFiling: Q4 2025

**Rock Springs Capital Management LP** manages $1.9B across a portfolio of 98 positions, exhibiting a concentrated, deep-value approach. The fund's top holdings reveal significant allocations to biotechnology and specialized healthcare names, notably LLY at $113.3M and RVMD at $106.4M. Further substantial exposure includes ARGX ($86.8M) and TVTX ($84.5M), signaling a focused conviction in high-growth, science-driven sectors. This positioning suggests a tactical, research-intensive mandate targeting asymmetric upside potential within the life sciences landscape.

Total AUM
$1.9B
QoQ Performance
+14.0%
Positions
97
Top 10 Concentration
39.9%
Latest Filing
Q4 2025

Top Holdings Allocation

LLY
RVMD
LLY5.8%
RVMD5.5%
ARGX4.5%
TVTX4.3%
MDGL4.2%
RYTM3.8%
EXK3.1%
MIRM3.1%

๐Ÿ“ˆ Biggest Buys

UNH
UNITEDHEALTH GROUP INC
NEW
0.7% of portfolio
XBI
SPDR SERIES TRUST
+46.3%
1.4% of portfolio
IMNM
IMMUNOME INC
NEW
0.4% of portfolio
RAPT
RAPT THERAPEUTICS INC
NEW
0.4% of portfolio
CNTA
CENTESSA PHARMACEUTICALS PLC
+368.0%
0.4% of portfolio

๐Ÿ“‰ Biggest Sells

ARGX
ARGENX SE
-27.7%
4.5% of portfolio
GPCR
STRUCTURE THERAPEUTICS INC
-21.3%
2.7% of portfolio
IM8N
INSMED INC
-17.1%
2.9% of portfolio
CDTX
CIDARA THERAPEUTICS INC
-17.9%
2.3% of portfolio
COGT
COGENT BIOSCIENCES INC
-15.8%
1.6% of portfolio

Sector Breakdown

Other92.5%
Healthcare7.5%

๐Ÿšช Exited Positionssold since Q3 2025

2GH
MERUS N V
SOLD
$56.2M
AKRO
AKERO THERAPEUTICS INC
SOLD
$29.7M
MREO
MEREO BIOPHARMA GROUP PLC
SOLD
$9.4M
WST
WEST PHARMACEUTICAL SVSC INC
SOLD
$2.6M
KRRO
KORRO BIO INC
SOLD
$1.7M
+7 more exited positions

Changes from Q3 2025

NEW18 new positions
โ†‘32 increased
โ†“27 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023