Paradigm Biocapital Advisors LP
•CIK: 1855655•Filing: Q4 2025
Paradigm Biocapital Advisors LP, led by co-founders Dr. David E. Williams and Dr. John P. Kane, focuses on early-stage biotech investments, currently managing $3.9 billion in assets with a portfolio of 30 positions. Notably, the fund has recently added OLMA and EYPT, achieving significant gains of 184% and 136% respectively, while exiting JANX and NTRSO, and introducing new positions in ORKA, LXEO, and TERN.
Total AUM
$3.7B
+ $182.9M in options
QoQ Performance
+30.6%
Positions
29
+ 1 option
Top 10 Concentration
70.9%
Latest Filing
Q4 2025
Top Holdings Allocation
NUVL
RVMD
ACLX
GMAB
TARS
NUVL13.5%
RVMD13.5%
ACLX9.5%
GMAB5.5%
TARS5.4%
ABVX4.9%
OLMA4.8%
PCVX4.8%
📈 Biggest Buys
📉 Biggest Sells
Sector Breakdown
Other100.0%
🚪 Exited Positionssold since Q3 2025
—
PHARVARIS N V
SOLD
$45.8M
+7 more exited positions
Changes from Q3 2025
NEW8 new positions
↑12 increased
↓7 decreased
Historical Filings
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023