Data as of Q4 2025 (Dec 31, 2025)

MPM BioImpact LLC

โ€ขCIK: 1687078โ€ขFiling: Q4 2025

**MPM BioImpact LLC** is a specialized investment vehicle managing $874M across 38 concentrated positions. The fund exhibits significant conviction in the biotechnology sector, with top holdings including CGEM at $79.2M and MDGL at $56.4M. Notable allocations also include LQDA ($48.3M), TRVI ($41.2M), and EWTX ($41.1M). This portfolio structure suggests a deep, research-driven approach targeting high-growth opportunities within the life sciences landscape.

Total AUM
$874.0M
QoQ Performance
+43.1%
Positions
38
Top 10 Concentration
49.8%
Latest Filing
Q4 2025

Top Holdings Allocation

CGEM
MDGL
LQDA
CGEM9.1%
MDGL6.4%
LQDA5.5%
TRVI4.7%
EWTX4.7%
RVMD4.6%
AGIO4.1%
QURE3.8%

๐Ÿ“ˆ Biggest Buys

LQDA
Liquidia Corp
+600.4%
5.5% of portfolio
AGIO
Agios Pharmaceuticals Inc
NEW
4.1% of portfolio
QURE
Uniqure NV
NEW
3.8% of portfolio
ALMS
Alumis Inc
NEW
2.7% of portfolio
CRVS
Corvus Pharmaceuticals Inc
NEW
2.4% of portfolio

๐Ÿ“‰ Biggest Sells

SRPT
Sarepta Therapeutics Inc
-90.0%
0.2% of portfolio
RCKT
Rocket Pharmaceuticals, Inc.
-59.4%
0.6% of portfolio
CNTX
Context Therapeutics Inc
-27.4%
1.8% of portfolio
MDGL
Madrigal Pharmaceuticals Inc
-3.6%
6.4% of portfolio
EWTX
Edgewise Therapeutics Inc
-3.8%
4.7% of portfolio

Sector Breakdown

Other100.0%

๐Ÿšช Exited Positionssold since Q3 2025

RNAGBP
Avidity Biosciences Inc
SOLD
$33.1M
ZLAB
Zai Lab Ltd
SOLD
$25.3M
CMPX
Compass Therapeutics, Inc.
SOLD
$17.8M
ALKS
Alkermes Plc
SOLD
$16.5M
VERA
Vera Therapeutics Inc.
SOLD
$16.4M
+12 more exited positions

Changes from Q3 2025

NEW15 new positions
โ†‘6 increased
โ†“16 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023