Data as of Q4 2025 (Dec 31, 2025)

Foresite Capital Management IV, LLC

โ€ขCIK: 1704132โ€ขFiling: Q4 2025

**Foresite Capital Management IV, LLC** manages $230M across a concentrated portfolio of seven positions. The fund exhibits a significant overweighting in **BLK**, representing $132.6M of its total assets. Further notable allocations include **CYTK** at $29.1M and **LYEL** at $24.6M. This structure indicates a focused, high-conviction approach within its current investment mandate.

Total AUM
$229.7M
QoQ Performance
+25.8%
Positions
7
Top 10 Concentration
100.0%
Latest Filing
Q4 2025

Top Holdings Allocation

Phar
CYTK
LYEL
MAZE
Pharvaris57.7%
CYTK12.7%
LYEL10.7%
MAZE9.4%
RLAY3.7%
XENE3.1%
ALEC2.6%

๐Ÿ“ˆ Biggest Buys

ALEC
Alector, Inc.
NEW
2.6% of portfolio

๐Ÿ“‰ Biggest Sells

No reductions this quarter

Sector Breakdown

Other100.0%

Changes from Q3 2025

NEW1 new position

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023