Data as of Q4 2025 (Dec 31, 2025)

Exome Asset Management LLC

โ€ขCIK: 2011932โ€ขFiling: Q4 2025

**Exome Asset Management LLC** manages $209M across a portfolio of 60 positions, exhibiting a concentrated, sector-specific investment mandate. The fund's top holdings reveal significant allocations to biotechnology and healthcare, notably PRAX ($17.1M) and COGT ($10.9M). Further concentration is evident with positions in GH ($10.0M) and ISI ($9.2M), suggesting deep conviction in specific growth catalysts within the life sciences sector. This structure points to a high-conviction, research-intensive approach targeting outsized returns from specialized market segments.

Total AUM
$202.4M
+ $6.7M in options
QoQ Performance
+33.7%
Positions
53
+ 7 options
Top 10 Concentration
42.7%
Latest Filing
Q4 2025

Top Holdings Allocation

PRAX
COGT
PRAX8.2%
COGT5.2%
GH4.8%
ISI4.4%
LLY4.0%
CYTK3.8%
WVE3.4%
VERA3.0%

๐Ÿ“ˆ Biggest Buys

WVE
WAVE LIFE SCIENCES LTD
NEW
3.4% of portfolio
ELV
ELEVANCE HEALTH INC FORMERLY
NEW
2.9% of portfolio
JAZZ
JAZZ PHARMACEUTICALS PLC
NEW
2.2% of portfolio
AGIO
AGIOS PHARMACEUTICALS INC
NEW
1.8% of portfolio
ELVN
ENLIVEN THERAPEUTICS INC
NEW
1.6% of portfolio

๐Ÿ“‰ Biggest Sells

PRAX
PRAXIS PRECISION MEDICINES I
-43.0%
8.2% of portfolio
COGT
COGENT BIOSCIENCES INC
-31.1%
5.2% of portfolio
BBIO
BRIDGEBIO PHARMA INC
-39.3%
3.0% of portfolio
NBP
NOVABRIDGE BIOSCIENCES
-65.3%
1.0% of portfolio
ARWR
ARROWHEAD PHARMACEUTICALS IN
-52.4%
1.6% of portfolio

Sector Breakdown

Other95.0%
Healthcare5.0%

๐Ÿšช Exited Positionssold since Q3 2025

ETNBGBP
89BIO INC
SOLD
$4.0M
APGE
APOGEE THERAPEUTICS INC
SOLD
$3.8M
CVS
CVS HEALTH CORP
SOLD
$3.3M
SLNO
SOLENO THERAPEUTICS INC
SOLD
$3.3M
AKRO
AKERO THERAPEUTICS INC
SOLD
$2.8M
+29 more exited positions

Changes from Q3 2025

NEW26 new positions
โ†‘5 increased
โ†“16 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023