EcoR1 Capital, LLC
•CIK: 1587114•Filing: Q4 2025
**EcoR1 Capital, LLC** manages $2.2B across a concentrated portfolio of 28 positions. The fund exhibits significant conviction in the life sciences sector, with its top holding in ZYME representing $604.8M, accounting for approximately 27.5% of reported assets. Further notable allocations include ANAB at $382.0M and MRX at $290.1M. This structure indicates a deep, high-conviction approach targeting disruptive growth within specialized healthcare markets.
Total AUM
$2.2B
+ $12.2M in options
QoQ Performance
+3.6%
Positions
27
+ 1 option
Top 10 Concentration
85.9%
Latest Filing
Q4 2025
Top Holdings Allocation
ZYME
ANAB
JAZZ
CRNX
ZYME27.9%
ANAB17.6%
JAZZ13.4%
CRNX9.2%
CNTA3.6%
CRSP3.4%
MBX3.1%
IMNM2.8%
📈 Biggest Buys
📉 Biggest Sells
Sector Breakdown
Other100.0%
🚪 Exited Positionssold since Q3 2025
+6 more exited positions
Changes from Q3 2025
NEW9 new positions
↑2 increased
↓3 decreased
Historical Filings
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023