DAFNA Capital Management LLC
•CIK: 1389933•Filing: Q4 2025
**DAFNA Capital Management LLC** manages $431M across a concentrated portfolio of 77 positions. The fund exhibits significant conviction in specific sectors, highlighted by its top holdings including RVMD at $48.1M and XBI at $41.0M. Further substantial allocations are noted in RJR1 ($31.5M) and ATRC/CYTK, each representing $23.6M. This positioning suggests a tactical, high-conviction approach targeting specific market opportunities.
Total AUM
$425.1M
QoQ Performance
+6.4%
Positions
76
Top 10 Concentration
55.6%
Latest Filing
Q4 2025
Top Holdings Allocation
RVMD
XBI
RJR1
ATRC
CYTK
RVMD11.3%
XBI9.7%
RJR17.4%
ATRC5.6%
CYTK5.5%
IDYA4.1%
AXGN3.7%
XENE3.0%
📈 Biggest Buys
📉 Biggest Sells
Sector Breakdown
Other100.0%
🚪 Exited Positionssold since Q3 2025
+5 more exited positions
Changes from Q3 2025
NEW12 new positions
↑16 increased
↓29 decreased
Historical Filings
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023