Data as of Q4 2025 (Dec 31, 2025)

Avoro Capital Advisors LLC

โ€ขCIK: 1633313โ€ขFiling: Q4 2025

Avoro Capital Advisors LLC, led by the seasoned investor team of Avi Rozen and Oren Rozen, manages $9.1 billion with a focus on biotech and healthcare, sectors where they hold significant positions like UTH and MDGL. Recently, the fund has increased its stake in ARWR by 88% and added GPCR by 216%, while exiting VYLD and cutting ASND entirely, reflecting a strategic pivot towards high-growth biotech opportunities.

Total AUM
$9.1B
+ $625.0K in options
QoQ Performance
+17.5%
Positions
32
+ 1 option
Top 10 Concentration
73.5%
Latest Filing
Q4 2025

Top Holdings Allocation

UTH
MDGL
ARGX
KRYS
ARWR
KYMR
GPCR
UTH14.0%
MDGL11.6%
ARGX9.2%
KRYS7.8%
ARWR7.8%
KYMR6.4%
GPCR5.0%
RNAGBP4.3%

๐Ÿ“ˆ Biggest Buys

CELC
CELCUITY INC
NEW
3.4% of portfolio
UTH
UNITED THERAPEUTICS CORP
+28.9%
14.0% of portfolio
XBI
SPDR SERIES TRUST - S&P BIOTECH
NEW
2.8% of portfolio
โ€”
TERNS PHARMACEUTICALS INC
NEW
1.9% of portfolio
RVMD
REVOLUTION MEDICINES INC
NEW
1.9% of portfolio

๐Ÿ“‰ Biggest Sells

RNAGBP
AVIDITY BIOSCIENCES INC
-28.6%
4.3% of portfolio
ASNDCALL
ASCENDIS PHARMA
-99.0%
0.0% of portfolio
ALKS
ALKERMES PLC
-37.5%
0.4% of portfolio
ARWR
ARROWHEAD PHARMACEUTICALS INC
-2.5%
7.8% of portfolio
VERA
VERA THERAPEUTICS INC
-5.2%
3.3% of portfolio

Sector Breakdown

Other100.0%

๐Ÿšช Exited Positionssold since Q3 2025

2GH
MERUS N V
SOLD
$333.5M
AKRO
AKERO THERAPEUTICS INC
SOLD
$187.8M
โ€”
TOURMALINE BIO INC
SOLD
$122.2M
AM6
AMICUS THERAPEUTICS INC.
SOLD
$118.4M
ETNBGBP
89BIO INC
SOLD
$93.9M
+3 more exited positions

Changes from Q3 2025

NEW11 new positions
โ†‘9 increased
โ†“7 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023