Data as of Q4 2025 (Dec 31, 2025)

Avidity Partners Management LP

โ€ขCIK: 1791827โ€ขFiling: Q4 2025

**Avidity Partners Management LP** manages $347M across a focused portfolio of 39 positions. The fund exhibits significant concentration in the healthcare sector, with top holdings including DNTH at $86.7M and CGON at $61.1M. Further substantial allocations are visible in JBIO ($21.6M) and ORKA ($20.0M). This structure suggests a deep, conviction-driven approach targeting high-potential opportunities within specialized healthcare verticals.

Total AUM
$346.7M
QoQ Performance
-21.1%
Positions
39
Top 10 Concentration
71.9%
Latest Filing
Q4 2025

Top Holdings Allocation

DNTH
CGON
JBIO
ORKA
DNTH25.0%
CGON17.6%
JBIO6.2%
ORKA5.8%
TEVA3.8%
BSX3.1%
MDT3.0%
CATX2.5%

๐Ÿ“ˆ Biggest Buys

ALNY
ALNYLAM PHARMACEUTICALS INC
NEW
2.4% of portfolio
ICLR
ICON PLC
NEW
1.7% of portfolio
AG8
AGILENT TECHNOLOGIES INC
NEW
1.6% of portfolio
CNC
CENTENE CORP DEL
NEW
1.4% of portfolio
RGEN
REPLIGEN CORP
+115.9%
2.4% of portfolio

๐Ÿ“‰ Biggest Sells

DNTH
DIANTHUS THERAPEUTICS INC
-34.3%
25.0% of portfolio
NTRA
NATERA INC
-83.2%
0.8% of portfolio
DHR
DANAHER CORPORATION
-68.9%
1.1% of portfolio
MDT
MEDTRONIC PLC
-43.5%
3.0% of portfolio
TMO
THERMO FISHER SCIENTIFIC INC
-64.6%
1.1% of portfolio

Sector Breakdown

Other92.4%
Healthcare7.6%

๐Ÿšช Exited Positionssold since Q3 2025

BMY
BRISTOL-MYERS SQUIBB CO
SOLD
$11.6M
โ€”
METSERA INC
SOLD
$7.4M
UNH
UNITEDHEALTH GROUP INC
SOLD
$6.1M
ARVN
ARVINAS INC
SOLD
$6.0M
JNJ
JOHNSON & JOHNSON
SOLD
$5.0M
+10 more exited positions

Changes from Q3 2025

NEW11 new positions
โ†‘5 increased
โ†“19 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023