Data as of Q4 2025 (Dec 31, 2025)

ACUTA CAPITAL PARTNERS, LLC

โ€ขCIK: 1582844โ€ขFiling: Q4 2025

**ACUTA CAPITAL PARTNERS, LLC** manages $147M across a concentrated portfolio of 30 positions. The fund exhibits a significant overweighting toward specialized biotech and healthcare names, evidenced by top holdings including TERN at $25.7M and PRAX at $24.5M. Notable allocations also include CDTX ($19.7M) and OCUL ($12.8M), suggesting a focused, high-conviction approach within the life sciences sector. This structure indicates a deep, research-driven mandate targeting specific growth catalysts within the industry.

Total AUM
$147.3M
QoQ Performance
+52.2%
Positions
30
Top 10 Concentration
79.4%
Latest Filing
Q4 2025

Top Holdings Allocation

TERN
PRAX
CDTX
OCUL
WHWK
TERN17.5%
PRAX16.6%
CDTX13.4%
OCUL8.7%
WHWK5.6%
DRUG4.5%
CMPX4.0%
JAZZ3.3%

๐Ÿ“ˆ Biggest Buys

PRAX
PRAXIS PRECISION MEDICINES I
+66.9%
16.6% of portfolio
TERN
TERNS PHARMACEUTICALS INC
+26.7%
17.5% of portfolio
NERV
MINERVA NEUROSCIENCES
NEW
1.9% of portfolio
TNGX
TANGO THERAPEUTICS INC
NEW
1.7% of portfolio
DSGN
DESIGN THERAPEUTICS INC
NEW
1.0% of portfolio

๐Ÿ“‰ Biggest Sells

CDTX
CIDARA THERAPEUTICS INC
-37.0%
13.4% of portfolio
IM8N
INSMED INC
-32.9%
3.1% of portfolio
OCUL
OCULAR THERAPEUTIX INC
-9.6%
8.7% of portfolio
ARGX
ARGEN SE - ADR
-24.0%
2.8% of portfolio
DNTH
DIANTHUS THERAPEUTICS INC
-33.2%
0.5% of portfolio

Sector Breakdown

Other100.0%

๐Ÿšช Exited Positionssold since Q3 2025

โ€”
TOURMALINE BIO INC
SOLD
$12.8M
ASND
ASCENDIS PHA-ADR
SOLD
$1.9M
KRYS
KRYSTAL BIOTECH INC
SOLD
$1.9M
COGT
COGENT BIOSCIENCES INC
SOLD
$1.5M
FULC
FULCRUM THERAPEUTICS INC
SOLD
$525.7K

Changes from Q3 2025

NEW7 new positions
โ†‘4 increased
โ†“6 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023