SR ONE CAPITAL MANAGEMENT, LP
•CIK: 1910264•Filing: Q4 2025
**SR ONE CAPITAL MANAGEMENT, LP** manages $706M across a concentrated portfolio of 13 positions. The fund exhibits significant conviction in select names, with ZBIO representing the largest allocation at $182.9M. Further top holdings include ACLX at $153.0M and TFC-PR at $106.9M, indicating a focused, high-conviction investment mandate. This structure suggests a tactical approach targeting outsized returns within specific market sectors.
Total AUM
$706.4M
QoQ Performance
+2.2%
Positions
13
Top 10 Concentration
97.7%
Latest Filing
Q4 2025
Top Holdings Allocation
ZBIO
ACLX
CRSP
DSGN
MLYS
SPRY
ORIC
ZBIO25.9%
ACLX21.7%
CRSP15.1%
DSGN8.7%
MLYS8.0%
SPRY6.6%
ORIC5.3%
ALMS2.7%
📈 Biggest Buys
📉 Biggest Sells
MLYS
Mineralys Therapeutics Inc.
-26.0%
8.0% of portfolio
Sector Breakdown
Other100.0%
Changes from Q3 2025
NEW1 new position
↑2 increased
↓1 decreased
Historical Filings
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023