Data as of Q4 2025 (Dec 31, 2025)

Darwin Global Management, Ltd.

โ€ขCIK: 1839209โ€ขFiling: Q4 2025

Darwin Global Management, Ltd., led by founder and CEO John A. Overdeck, is known for its concentrated, long-term investment strategy, currently holding 73.8% of its assets in IMAX Corporation. The fund has recently increased its positions in CDTX and ABVX by 132% and 67%, respectively, while exiting UTH and DSECF, reflecting a focus on growth-oriented technology and healthcare sectors.

Total AUM
$4.9B
QoQ Performance
+37.3%
Positions
6
Top 10 Concentration
100.0%
Latest Filing
Q4 2025

Top Holdings Allocation

IM8N
BLTE
ABVX
IM8N73.8%
BLTE9.9%
ABVX8.9%
CDTX4.5%
WVE2.5%
CAPR0.5%

๐Ÿ“ˆ Biggest Buys

BLTE
BELITE BIO INC
NEW
9.9% of portfolio
WVE
WAVE LIFE SCIENCES LTD
NEW
2.5% of portfolio
IM8N
INSMED INC
+2.3%
73.8% of portfolio
CAPR
CAPRICOR THERAPEUTICS INC
NEW
0.5% of portfolio
ABVX
ABIVAX SA
+0.4%
8.9% of portfolio

๐Ÿ“‰ Biggest Sells

No reductions this quarter

Sector Breakdown

Other100.0%

๐Ÿšช Exited Positionssold since Q3 2025

UTH
UNITED THERAPEUTICS CORP DEL
SOLD
$317.6M
QURE
UNIQURE NV
SOLD
$23.8M

Changes from Q3 2025

NEW3 new positions
โ†‘2 increased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023