Data as of Q4 2025 (Dec 31, 2025)

Casdin Capital, LLC

โ€ขCIK: 1534261โ€ขFiling: Q4 2025

**Casdin Capital, LLC** manages $1.6B across a portfolio of 38 positions, exhibiting a concentrated, deep-value approach. The fund's largest allocation is to WGS at $391.1M, followed by RVMD ($205.3M) and BLFS ($144.0M). Notable holdings also include FLB ($113.6M) and RLAY ($110.0M), suggesting a focus on specific sector opportunities within its mandate. This structure indicates significant conviction in its top ten names, which account for over 80% of reported exposure.

Total AUM
$1.6B
QoQ Performance
+34.2%
Positions
38
Top 10 Concentration
79.5%
Latest Filing
Q4 2025

Top Holdings Allocation

WGS
RVMD
BLFS
FLB
RLAY
GPCR
WGS24.3%
RVMD12.8%
BLFS8.9%
FLB7.1%
RLAY6.8%
GPCR5.1%
ILMN4.9%
RNAGBP4.5%

๐Ÿ“ˆ Biggest Buys

GH
GUARDANT HEALTH INC
+280.0%
2.4% of portfolio
TXG
10X GENOMICS INC
NEW
1.4% of portfolio
DNLI
DENALI THERAPEUTICS INC
+106.7%
1.9% of portfolio
FLB
STANDARD BIOTOOLS INC
+14.5%
7.1% of portfolio
RLAY
RELAY THERAPEUTICS INC
+14.7%
6.8% of portfolio

๐Ÿ“‰ Biggest Sells

RNAGBP
AVIDITY BIOSCIENCES INC
-43.8%
4.5% of portfolio
GPCR
STRUCTURE THERAPEUTICS INC
-24.4%
5.1% of portfolio
BLFS
BIOLIFE SOLUTIONS INC
-11.2%
8.9% of portfolio
RVMD
REVOLUTION MEDICINES INC
-2.6%
12.8% of portfolio

Sector Breakdown

Other98.3%
Healthcare1.7%

๐Ÿšช Exited Positionssold since Q3 2025

EXK
EXACT SCIENCES CORP
SOLD
$4.9M

Changes from Q3 2025

NEW7 new positions
โ†‘9 increased
โ†“4 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023