Palo Alto Investors LP
•CIK: 1306923•Filing: Q4 2025
**Palo Alto Investors LP** manages $718M across a concentrated portfolio of 49 positions. The fund exhibits significant conviction in select names, with top holdings including IM8N at $85.2M and AM6 at $74.1M. Further substantial allocations are evident in PTCT ($68.7M) and ACAD ($66.3M). This structure suggests a deep-value, high-conviction approach targeting established growth leaders.
Total AUM
$718.4M
QoQ Performance
+32.9%
Positions
49
Top 10 Concentration
67.8%
Latest Filing
Q4 2025
Top Holdings Allocation
INSM
AM6
PTCT
ACAD
BMRN
INSM11.9%
AM610.3%
PTCT9.6%
ACAD9.2%
BMRN6.2%
ANAB4.7%
BIIB4.5%
DYN4.0%
📈 Biggest Buys
📉 Biggest Sells
Sector Breakdown
Other99.9%
Healthcare0.1%
🚪 Exited Positionssold since Q3 2025
Changes from Q3 2025
NEW8 new positions
↑12 increased
↓13 decreased
Historical Filings
Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023Q3 2023Q2 2023Q1 2023Q4 2022