Data as of Q4 2025 (Dec 31, 2025)

DEERFIELD MANAGEMENT COMPANY, L.P.

โ€ขCIK: 1009258โ€ขFiling: Q4 2025

Deerfield Management Company, L.P., led by David M. Herro, is known for its concentrated, long-term investment strategy, currently managing $7.8 billion in assets across 150 positions. Notably, the fund has recently increased its stakes in Praxair and GPC Biotech by 497% and 411%, respectively, while exiting positions in VYLD and BMY, reflecting a focus on industrial and biotech sectors.

Total AUM
$6.8B
+ $29.5M in options
QoQ Performance
+13.4%
Positions
139
+ 1 option
Top 10 Concentration
55.6%
Latest Filing
Q4 2025

Top Holdings Allocation

NUVL
NUVL25.2%
COGT4.7%
PRAX3.9%
CNC3.9%
VTRS3.7%
RVMD3.4%
UTH3.0%
VERA3.0%

๐Ÿ“ˆ Biggest Buys

CELC
CELCUITY INC
+133.7%
2.5% of portfolio
LEGN
LEGEND BIOTECH CORP
+100.2%
1.9% of portfolio
STOK
STOKE THERAPEUTICS INC
NEW
0.8% of portfolio
ARWR
ARROWHEAD PHARMACEUTICALS IN
+84.6%
1.8% of portfolio
LNTH
LANTHEUS HLDGS INC
NEW
0.8% of portfolio

๐Ÿ“‰ Biggest Sells

INDV
INDIVIOR PLC
-51.4%
1.8% of portfolio
CNC
CENTENE CORP DEL
-28.7%
3.9% of portfolio
NUVL
NUVALENT INC
-4.1%
25.2% of portfolio
RVMD
REVOLUTION MEDICINES INC
-20.7%
3.4% of portfolio
VTRS
VIATRIS INC
-16.2%
3.7% of portfolio

Sector Breakdown

Other99.9%
Healthcare0.1%

๐Ÿšช Exited Positionssold since Q3 2025

2GH
MERUS N V
SOLD
$286.9M
BMY
BRISTOL-MYERS SQUIBB CO
SOLD
$105.4M
MRK
MERCK & CO INC
SOLD
$86.4M
PFE
PFIZER INC
SOLD
$84.2M
IM8N
INSMED INC
SOLD
$67.8M
+29 more exited positions

Changes from Q3 2025

NEW31 new positions
โ†‘36 increased
โ†“43 decreased

Historical Filings

Q4 2025Q3 2025Q2 2025Q1 2025Q4 2024Q3 2024Q2 2024Q1 2024Q4 2023